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It's important to note that Ozempic is not licensed for weight management and should not be used off-label for this purpose given current UK supply constraints

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Mechanically, given the sensitivity of Hippo signaling to physical force, the effect of the fibrotic extracellular matrix (ECM) and the thickened and sclerosed cortex of the polycystic ovaries, which contains more F-actin and collagen, is to downregulate Hippo signaling, resulting in YAP1 over-activation, and thus leading to stromal hypertrophy and over-proliferation of theca cells