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Risk of Esophageal and Gastric Cancer in Patients with Type 2 Diabetes Receiving Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs): A National Analysis

Additionally, GLP-1R activation results in transcription of genes involved in proliferation, neogenesis and apoptotic resistance in islet beta cells, expanding GLP-1s role from potentiating insulin secretion from islet beta cells to promoting their survival via translocation of pancreatic duodenal homeobox 1 (PDX-1) transcription factor to the nucleus 2,12,42

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Typically, payers have justified covering GLP-1 therapies by targeting co-morbidities rather than obesity alone

G protein-coupled receptor 17 (Gpr17) Gpr17, a G protein coupled receptor, is linked to the Gi alpha subunit or the Gq alpha subunit to achieve its function