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The causative role of GLP-1 in T2DM remission after bariatric surgery will be difficult to tease apart in humans, but other predictive factors such as duration of disease, and thus the degree of -cell destruction before surgery, may be more critical in determining whether -cells can recover sufficiently to resolve T2DM (84)

GLP-1s work via the endocrine system and may trigger malignancies in these patients

Additionally, deficiencies in insulin availability are known to contribute to neurodegenerative conditions, but GLP-1s amplify insulin signaling in brain cells, increasing insulin sensitivity in the neurons

However, individual outcomes vary based on how well you've established lasting eating and activity habits during treatment

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