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Coupled with provider pressure to simply lose the weight in order to solve concerns such as diabetes and heart disease, factors such as insulin resistance, menopause, metabolic disorders, inflammation, and hunger/satiety hormone imbalance (often due to chronic dieting) are all but ignored, and responsibility is placed solely on the patient

This theory is supported by the discovery of adrenal atrophy upon autopsy ( CAI in PWS is not well understood, as studies have reported varying results (ranging from 0% to 60%) using different dynamic tests, such as the insulin tolerance test (ITT), metyrapone test (MT), glucagon test (GT), and the currently most used low-dose and standard dose Synacthen stimulation test (LDSST and SDSST) ( Table 1 ) ( Table 1 Summary of the studies with stimulation tests for central adrenal insufficiency in PWS

doi: 10.1210/me.2014-1346 44

The components of the program provide scaffolding as you work toward your goal weight
