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49 The glucose-lowering potential of cotadutide (a GLP-1/GCG RA) was seen in a Phase IIa study, in which the post-prandial area under curve was significantly reduced, and 3.4% weight loss was achieved after 49 days, in adults who are overweight with T2D

FDA prescribing information for medications like Wegovy (semaglutide) and Mounjaro (tirzepatide) includes warnings that acute gallbladder disease has been reported in clinical trials

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Conversely, acute chemogenetic activation of those neurons fails to increase, and rather transiently reduces, energy expenditure [357]