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GLP-1 medications have quickly changed the landscape of weight management and metabolic health

When people stopped taking one of the new weight-loss jabs they regained around 60% of their lost weight.

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the endocytic adaptor Epsin binds to the ubiquitinated intracellular domain, and the resulting Clathrin-mediated endocytosis exerts a pulling force that exposes the cleavage site in the NRR [[4][4][6][5]]