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Thanks for the great research This lines up with what we see physiologicallyGLP-1 seems to shift autonomic balance toward sympathetic dominance, which fitness can partly buffer at the level of heart rate but not at the deeper vagal modulation reflected in HRV

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The primary outcome of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke occurred in 6.6% of the semaglutide group and 8.9% of the placebo group (HR 0.74

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