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However, challenges including high costs exceeding $1000 per month, gastrointestinal side effects, nutritional deficiencies, and low long-term adherence with subsequent weight regain [5] [6] warrant careful consideration

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10.1371/journal.pone.0063626 [DOI] [PMC free article] [PubMed] [Google Scholar] 129.Fukuda-Tsuru S, Kakimoto T, Utsumi H, Kiuchi S, Ishii S

We dont include any ingredient in our formulation which has not been clinically trialed extensively, he said