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Semaglutide operates by targeting the appetite-regulating centers in the brain, which influences patients feelings of hunger and fullness

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Healthy storage of adipose tissue delays the progressive insulin resistance associated with obesity 74 , providing a plausible hypothesis that if GIPR agonism in adipose tissue can promote lipid storage in the correct location, this could result in positive effects on insulin sensitivity

The guidance states that doctors may prescribe antibiotics for some patients, including those who are immunocompromised or medically frail
