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Key findings from the Phase 2 trial included: Dose-dependent weight loss , with greater reductions observed at higher doses Significant improvements in waist circumference , blood pressure , and lipid profiles Reductions in fasting glucose and insulin resistance markers, though the clinical significance of these findings in people with type 2 diabetes requires further investigation Weight loss appeared to continue throughout the 48-week period without a clear plateau at the highest doses Whilst these results are encouraging, it is important to contextualise them appropriately

The authors point out that other studies have shown heightened levels of circulating GLP-1 in critically ill patients7, who would presumably have some degree of impaired intestinal barrier function

Q: How long does it take to notice effects

The 8mg dose produced 22.8% average weight loss at 48 weeks in the phase 2 trial, with 100% of participants losing at least 5% and 91% losing at least 10% of body weight

Open communication about symptom severity helps optimize both safety and effectiveness of weight loss injection therapy