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The relationship between obesity and bone metabolism is paradoxical, as increased mechanical loading is traditionally associated with higher bone mineral density, yet adiposity-driven chronic inflammation and metabolic dysfunction impair bone quality

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Prescription GLP-1 Medications: Mechanism, Cost, and Clinical Evidence GLP-1 receptor agonists (semaglutide, tirzepatide) work by increasing satiety signals in the brain, slowing gastric emptying, and improving insulin secretion

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We observed a sustained effect on pacemaker rate despite ivabradine blockade, both in vivo and in the isolated superfused sinus node, suggesting that GLP-1s mode of action is not mediated via HCN channels