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Alloc in the Fmoc-Lys(Alloc)-OH in the preparation method is removed twice with 5-10 equivalents of morpholine (or 5-10 equivalents of phenylsilane as an alternative thereof) and 0.1-0.3 equivalents of Pd(PPh 3 ) 4 for 10-30 min each time, wherein CH 2 Cl 2 is used as a solvent in the removal

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Compounding is now limited to legally compliant circumstances., Is compounded tirzepatide still allowed

doi:10.1038/s41591-022-02026-4 Geer JH, Hilbert J
