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While auto-injector pens manufactured by pharmaceutical companies are safe, Dr

Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)

Further studies are needed to investigate the bone impact of GLP-1Ra, dual- and triple-receptor agonists for GLP-1, glucose-dependent insulin releasing polypeptide (GIP), and glucagon in PwO

Peripherally, GLP-1R enhances glucose control by increasing insulin secretion and reducing glucagon production, delays gastric emptying and regulates intestinal hormones

Watada H, Kaneko S, Komatsu M, Agner BR, Nishida T, Ranthe M, Nakamura J