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Mounted on the membrane-facing surface of the cytoplasmic tip of TM6, compound 2 was able to induce a newly discovered ECD conformation allowing its N-terminal helix to penetrate into the TMD core, a key step for the ago-allosterism observed experimentally, consistent with the intrinsic agonism hypothesis for the ECD of GLP-1R 40

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Patients may benefit from evaluation if they have obesity, have overweight with related medical conditions, have struggled with weight loss despite lifestyle changes, or want medically supervised treatment options

Regulation (EC) No 1252/2014 establishes GMP principles specifically for active substances used in human medicines