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This analysis also assesses whether combination therapy can be a synergistic approach that may benefit patients but is still underutilized because of the lack of clear guidelines, the associated costs, and disparities in accessibility

Indicator #1 Unprecedented Growth: GLP-1 Products Redefine Revenue Trajectories (FIGURE 1) Since launch, GLP-1 drugs have generated a cumulative $71 billion in US revenue and they are projected to amass $400 billion more in the coming years to reach $470 billion by 2030

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by 2045

In these cases, the most commonly reported effects were gastrointestinal symptomsprimarily severe nausea, vomiting, and diarrheawhich can lead to dehydration and electrolyte disturbances if not managed appropriately