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The mechanistic advantages of dual agonism appear to stem from complementary effects on multiple physiological systems, including enhanced pancreatic function, optimized central nervous system regulation of energy homeostasis, and improved metabolic flexibility

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Stress management techniques such as cognitive behavioural therapy for insomnia (CBT-I), mindfulness meditation, or progressive muscle relaxation can address anxiety about sleep itself, which often perpetuates insomnia

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While it may feel counterintuitive to go back to a lower dose after building tolerance to another GLP-1 medication, this approach helps prevent gastrointestinal intolerance and supports better long-term adherence