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evidence from uncontrolled designs (case reports, case series, pharmacovigilance analyses) was initially rated very low certainty, as these designs are inherently uncontrolled and start below the lowest GRADE tier
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That message is spreading like wildfire on TikTok about berberine, a compound found in plants such as barberry, golden seal and meadow rue that have a long history of use in Ayurvedic and Traditional Chinese Medicine

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