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Semaglutide also has a longer half-life than the older GLP-1s and may have a stronger effect on receptors in the brain, which could help explain the difference in findings, Moreno adds

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This analytical approach proves particularly valuable for detecting subtle modifications including oxidation, deamidation, or other chemical changes that might not significantly affect HPLC retention behavior but could impact biological activity

Wegovys active ingredient, semaglutide, works by mimicking the natural hormone GLP-1, which is crucial for regulating appetite, blood sugar levels, and insulin release