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The once-weekly injection starts at 0.25mg, gradually increasing to a maintenance dose of 2.4mg over 16 weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] 434.Zhang H., Sturchler E., Zhu J., Nieto A., Cistrone P.A., Xie J

This result was partly driven by the high event rate in patients with CKD, which was almost twice than in patients with normal renal function [39]

The most common adverse events were nausea, vomiting, diarrhoea and constipation

These factors are manageable with proper nutrition, hydration, and medical monitoring
