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[1] [2] No signal suggesting an increased incidence of diverticulitis has emerged from these large-scale studies involving thousands of participants

Similarly, the EXSCEL trial showed that the incidence of three-point MACE with 2 mg once-weekly exenatide was not significantly different from placebo in 14,752 patients living with T2DM (median follow-up of 3.2 years) (Holman et al

Clinical trials show tirzepatide producing slightly greater average weight loss, with participants losing 15 to 21 percent of body weight compared to 15 to 17 percent with semaglutide

People continue to file lawsuits due to these negative outcomes

Relative to placebo, the reduction of diastolic BP only reached significance for the treatment of exenatide 10 g/twice daily (1.08 mmHg) [620]