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At a population level, 70% of people prefer oral medications over injections

30,35 At therapeutic doses, whether GLP-1RA can directly affect the CNS depends on the drugs properties

One study found that people who injected the medication into the fat on their stomach absorbed the medication more quickly than those who used their thigh as an injection site

Another important mechanism involves mitochondrial health

Conversely, acute chemogenetic activation of those neurons fails to increase, and rather transiently reduces, energy expenditure [357]
