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Abbreviations T2D type 2 diabetes GLP-1 glucagon-like peptide 1 RA receptor agonist GIP gastric inhibitory polypeptide GCG glucagon RCT randomized controlled trial PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analysis PROSPERO International Prospective Register of Systematic Reviews BMI body mass index HbA1c glycated hemoglobin SBP systolic blood pressure DBP diastolic blood pressure HDL high-density lipoprotein LDL low-density lipoprotein VLDL very-low-density lipoprotein AST aspartate aminotransferase ALT alanine aminotransferase TEAEs treatment-emergent adverse events Rob-2 Cochrane Collaboration tool for assessing risk of bias in randomized trials GRADE Grading of Recommendation, Assessment, Development and Evaluation WMD weighted mean difference SMD standardized mean difference RR risk ratio CI confidence interval 1

People using semaglutide who also drink face a compounded risk: the medication is already working to lower glucose, and alcohol amplifies that effect

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AKKERMANSIA MUCINIPHILA AND MUCIN DEGRADATION The best-characterized mucin-degrading microbe to date is A

Reduced earning capacity if your condition affects long-term employment