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Phase 3: Optimization (weeks 13 and beyond) At maintenance dose with stabilized side effects, your injection day becomes primarily about consistency and lifestyle fit
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Reduced caloric intake, weight loss, and metabolic changes all contribute

This analysis examines the evidence supporting dual agonism through the clinical development of tirzepatide, focusing on its efficacy, safety profile, and mechanistic rationale

Long-term safety signals, such as thyroid C-cell tumor risk, were seen in rodents but are unproven in humans
