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Annual kidney function screening (eGFR) is prudent, as GLP-1 medications should be used cautiously when eGFR falls below 15

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PI3K/mTOR Axis Mediates GLP-1R Signalling Actions on Glucose Metabolism GLP-1 can regulate cell size, function and proliferation in -cells via PI3K/mTOR pathway 25, 26

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Interestingly, GLP-1 signaling in the hippocampus has been described to play a direct and crucial role in regulating learning and memory, independent of motor, stress, or nociceptive impacts
