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it only has three to four days before the next dose arrives

9 The HbA1c reduction was sustained as far out as 78 weeks (58% of patients) and 104 weeks (10% of patients)

Tirzepatide vs semaglutide dosing Key differences : Tirzepatide : Dual agonist (GLP-1 + GIP) Higher starting dose (2.5mg vs 0.25mg) Faster titration schedule Typically higher maintenance dose Single agonist (GLP-1 only) Lower starting dose (0.25mg) Slower titration Lower maintenance dose Effectiveness : Tirzepatide produces 15-22% weight loss vs semaglutide's 15-17%