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Semaglutide (Wegovy) and liraglutide (Saxenda) are the primary weight loss injections licensed in the UK for weight management, and both list headaches as a recognised adverse effect in their Summary of Product Characteristics (SmPC)

41 However, there was an increase in heart rate and more serious cardiac events, such as arrhythmias and acute coronary syndrome, in patients treated with liraglutide

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Participants were randomized in a 1:1 ratio to receive once-weekly subcutaneous injections of semaglutide (2.4 mg) or a placebo