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THERMO GLP-1TM** also activates Hormone Sensitive Lipase (HSL) in adipose fat tissue setting in motion the breakdown of diglycerides and triglycerides (formed fat) in white adipose fat tissue (WAT) and mobilizing (releasing) them into the bloodstream for BAT fuel use, which literally burns fat to generate HEAT as opposed to needing the body to work (exercise) the fat calories off

Pfizers dose-optimization studies of once-daily formulations of danuglipron ( NCT06567327 and NCT06568731 ) met key pharmacokinetic objectives and confirmed a formulation and dose with the potential to deliver a competitive efficacy and tolerability profile in Phase 3 testing, based on earlier studies of twice-daily danuglipron