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This remains an area of active research rather than established clinical practice, and until adequately powered, randomised controlled trials assess the safety and efficacy of this specific combination, clinicians and patients should approach any claims about its benefits with appropriate scepticism

GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

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He added, "For folks whose business model is just asynchronous medicine, heading into a chatbot and then mailing you a compounded semaglutide and not having a real discussion with a physician with the ability to make the right choice for you, then this is probably a slap in the face