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GLP-1 medications can be combined with metformin for enhanced diabetes and weight management, but individual factors determine the best approach

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Blood was sampled throughout the day for analysis of plasma hormone and substrate concentrations

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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis