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"GLP-1 medications are intriguing from a cancer research perspective because they weren't designed for cancer therapy, but they do affect many different targets and pathways associated with cancer development, so we're eager to study them in this context," McDonald said

Berberine also inhibits PCSK9 (which increases the liver's ability to clear LDL from the bloodstream), inhibits DPP-4 (which extends the activity window of natural GLP-1), and directly affects gut microbiome composition in ways that may further support metabolic function

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GLP-1s were associated with a significant reduction in body weight in 15 studies and improved glycemic control in eight studies enrolling people with mental illness

Effects on weight reduction may contribute to improvements in metabolic function