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Embracing Disruption Premium brands, smaller waists: GLP-1s and the premiumization of healthcare GLP-1based anti-obesity medicines are incretin therapies that reduce appetite and improve cardiometabolic risk, shifting obesity treatment from short courses toward chronic medical management

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Eli Lillys tirzepatide gained FDA clearance for chronic weight management in late 2023, followed by European approval in early 2024, breaking Wegovys early monopoly

Quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) Total RNA was isolated with Superbrilliant 6 min High-quality RNA Extraction Kit (zsgentech, Tianjin, China), according to the manufacturer's instructions