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There were 93 patients (0.12%) with other optic nerve disorders in the semaglutide or tirzepatide group and 54 patients (0.07%) with other optic nerve disorders in the matched comparison group (hazard ratio, 1.65 [95% CI, 1.18-2.31])

Increased risk of mortality was also seen in patients with IBS-D taking diphenoxylate/atropine (HR = 1.89), which is a combined mu and muscarinic receptor agonist 41

The researchers further examined the effects of tesofensine on food intake by combining it with various drugs that block specific receptors in the brain
