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Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial The Lancet Diabetes & Endocrinology (2025) PubMed Retatrutide significantly reduced total body fat mass versus placebo and dulaglutide: -15.2% (4 mg), -26.1% (8 mg), -23.2% (12 mg) percent reduction from baseline

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It shows modeled drug levels for a specific protocol, which can help you understand what to expect and have informed conversations with your doctor

These medications are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)