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A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimers disease

Gene expression Selected genes were examined: (i) genes related to mitochondrial uncoupling ( UCP1, UCP2 ), (ii) the gene encoding transmembrane protein fibronectin type III domain-containing protein 5 precursor of irisin ( FNDC5 ), and (iii) the gene involved in NAD + synthesis ( NAMPT ) (Figure 4)

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