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AGEs react with amino acid residues in proteins, forming irreversible modifications that negatively affect sperm, including reduced sperm count, decreased motility, increased morphological abnormalities, residual histones, fish sperm protein deficiency, sperm DNA fragmentation, decreased antioxidant capacity in the testes, and elevated levels of receptor for advanced glycation end products (RAGE) and carboxymethyl lysine (CML) proteins [160]

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While this is generally not clinically significant, patients on multiple blood pressure medications should be monitored for hypotension, particularly if initiating magnesium supplementation alongside GLP-1 therapy, which may also contribute to modest blood pressure reductions through weight loss