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Exenatide treatment ameliorates these morphological alterations and inhibits the mitochondrial apoptotic pathway by suppressing cytochrome c release and favorably modulating the expression of pro-apoptotic (Bax, caspase-3) and anti-apoptotic (Bcl-2) proteins, thereby protecting RGC-5 cells from hyperglycemic injury [43]
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However, the studys limitations include the small number of available RCTs for tirzepatide and the lack of data on varying dosages
Notably, the study by Petkovic-Dabic et al
doi:10.1016/j.ijcard.2022.05.056 Tonhajzerova I, Sekaninova N, Bona Olexova L, Visnovcova Z
