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314,315 The dual inhibition of KPT-9274 allows targeting of NAD + regeneration and PAK4 signaling, which are essential for tumor development and survival, making KPT-9274 an attractive drug candidate for use in chemotherapy

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In the brain, GLP-1 receptors are present in regions critical for mood and motivation, including the hypothalamus, prefrontal cortex, ventral tegmental area (VTA), and nucleus accumbens [23]

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An oral form was recently approved in 2019 as a non-injection alternative for glycemic control [4]

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