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The study extended an earlier clinical trial known as SURMOUNT-1

At the N-terminus, the Tyr1 of Tirzepatide makes Van der Waals contact with the receptor residues, the Glu3 forms an ionic bond with Arg183 and a network of hydrogen bonds with Tyr145 and Ser381 of the receptor

Swallowing, talking, or moving the tongue disrupts the process

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According to the FDA-approved prescribing information, tirzepatide should be injected subcutaneously in one of three designated anatomical areas: the abdomen, thigh, or upper arm