glp 1 gip gcg Biology of Incretins: GLP-1 and Frontiers | GLP−1 receptor agonists

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These recommendations were motivated by the results of a recent cardiovascular outcomes trial (SELECT study), performed in obese subjects without diabetes, which reported a 20% reduction in the composite endpoint of cardiovascular death, non-fatal myocardial infraction and non-fatal stroke

The main roles of GLP-1 are stimulation of glucose-dependent insulin secretion, inhibition of postprandial glucagon release, delay of gastric emptying, and induction of pancreatic -cell proliferation [5]