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[DOI] [PubMed] [Google Scholar] 49.Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, et al
Building on striking phase 2 data which showed mean body weight reductions of approximately 24% at the highest dose over 48 weeks retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors, potentially offering a more powerful metabolic effect than existing treatments
Meta-analyses of berberine trials show modest reductions in hemoglobin A1c (approximately 0.5-0.7%) and fasting glucose, with variable effects on body weight, though many studies have methodological limitations and high heterogeneity
