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Increased Ca2+ levels also promote transcription of the proinsulin gene, thereby increasing the insulin content of the cell

On GLP-1, you may eat a fraction of what you used to, which means every bite matters, and every calorie needs to deliver real nutrition

Accordingly, the degree of DPP-4 inhibition attained in vivo is sufficient to increase circulating levels of intact (active) incretins by 2- to 4-fold and result in improved glycaemic control (118)

Given that the half-life of SGLT2 inhibitors varies from 11 to 13 hours, it seems reasonable to withhold these medications for three days (or five half-lives) before elective surgery