tirz vs retatrutide Mounjaro (Tirzepatide): Which is Better? Retatrutide vs Tirzepatide | FIRST

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Cani PD, Lecourt E, Dewulf EM, et al

All drugs come with risk, especially when used irresponsibly

Key Findings: No significant difference in overall adverse events between the two drugs Tirzepatide increased treatment discontinuation by 32% a crucial real-world consideration Better glycemic control (HbA1c targets) with tirzepatide, especially in early-stage disease Efficacy vs tolerability trade-off remains central to treatment decisions Clinical Insight: While tirzepatide offers strong metabolic benefits, our analysis highlights a critical reality: A treatment is only effective if patients can tolerate and continue it

The impact of GEP12 on food intake relative to baseline was notably less than that observed in response to GEP44 (at 5 nmol/kg/day: mean difference 36.5%, 95% CI 14.9% to 58.0%, p = 0.0009