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Interestingly, it was noted that, relative to semaglutide, tirzepatide treatment led to greater and more sustained reductions in food intake during the first 710 days of dosing associated with greater fat oxidation and increased energy expenditure after 7 days of drug treatment [84]

By doing so, in atherosclerotic plaques from murine aortas, GLP-1RAs regulate proinflammatory mediators and the phenotype of immune cells

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Therefore, GLP-1 has been extensively studied as a possible treatment of type 2 diabetes, and GLP-1 analogues and DPP-4 inhibitors are now widely in clinical use in these patients [711]

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