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187 High-fiber diets may assist in weight control but have been shown to accelerate lumbar spine bone density loss in postmenopausal women, and bone mass often fails to recover even after weight regain

Key findings at the highest dose (12mg weekly): Up to 24% mean body weight reduction over 48 weeks Significant reductions in fasting glucose and insulin resistance markers Meaningful reductions in liver fat content, relevant for participants with metabolic-associated fatty liver disease Once-weekly subcutaneous dosing was generally well-tolerated For context, semaglutide at its approved dose achieves approximately 1517% body weight reduction over 68 weeks

Kodera R, Shikata K, Kataoka HU, Takatsuka T, Miyamoto S, Sasaki M, et al

Their ability to address early-stage and progressive disease stages reinforces their importance in diabetes care

Department of Health and Human Services, Silver Spring, pp 15