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Among the risks, they say, is the heightened possibility of overdose for those who abruptly stop using the medications

A maintenance dose is typically 25 to 50% of the therapeutic dose

Shima Hadidchis practice

resume treatment if significant regain occurs Accept that some regain is normal and doesn't indicate failure Many individuals require ongoing medication for sustained weight loss maintenance, similar to other chronic disease treatments

Further scientific studies have identified GLP1 as a key player in the gut-brain regulatory axis, acting in the brain to dampen appetite-stimulating and food-related reward circuity, and in the periphery to heighten insulin secretion and sensitivity, reduce fat in the liver, and decrease gastric emptying and mobility