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Encouraged by such results, Saxenda expanded its indication to adolescent patients aged 12-18 with BMI equivalent to 30kg/ adults and weighing 60kg or more in December 2021

These interactions can modulate immune responses, reduce inflammatory signaling, strengthen tight junctions between intestinal cells (reducing permeability), and potentially support the environment in which L-cells function optimally

This interpretation is consistent with clinical observations that oral glutathione supplementation has limited bioavailability, favoring approaches that maintain precursor sufficiency instead of direct replacement [117,118,119]