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When Semaglutide Is Clearly Superior For the majority of weight loss patients, semaglutide is the superior choice: Significant weight loss needed (30+ lbs): Contrave's 58% weight loss is insufficient for patients with BMI 35+

PlexusDx's Precision Peptide Genetic Test ($99 add-on after your first month) analyzes four key variants linked to GLP-1 pathway response: GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, and MC4R rs17782313

GLP-1 receptor agonists, which activate GLP-1 receptors in the body, have proven to be a breakthrough in restoring that regulation

Patients can expect to shed about one to two pounds a week while taking Glp-1s

Additionally, the small sample sizes in the included studies led to some questionable observations