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Increased intestinal permeability ("leaky gut") allows bacterial lipopolysaccharides (LPS) to enter the bloodstream, triggering systemic inflammation that impairs insulin signaling
This suppresses production of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6 (the same IL-6 that paradoxically stimulates GLP-1 production in a feedback loop)
et al., 2023)
A., Norman, R
