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Moreover, several factors contribute to obesity-induced sympathetic activation, including hyperleptinemia, hyperinsulinemia, visceral obesity, sleep apnea, elevated non-esterified fatty acids, disturbances in nitric oxide levels, suppressed anger, altered eicosanoid metabolism, increased cytokine levels, and high levels of active tri-iodothyronine

Free radicals can damage cells and DNA, and may contribute to the aging process, as well as the development of a number of health conditions, such as heart disease and cancer

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