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The dose is typically started low and increased gradually, so the full therapeutic effect is reached over time

Iijima T, Shibuya M, Ito Y, Terauchi Y (2023) Effects of switching from liraglutide to semaglutide or dulaglutide in patients with type 2 diabetes: a randomized controlled trial

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In Experiment 1, acute semaglutide robustly disrupted alcohol discrimination, as evidenced by significant reductions in alcohol-appropriate responding at multiple doses in both sexes